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pentobarbital will lessen the extent or outcome of capivasertib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Robust or moderate CYP3A inducers reduce capivasertib exposure, which may lower efficacy.pentobarbital will decrease the extent or effect of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lessen the level or influence of docetaxel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.
pentobarbital decreases levels of atrasentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with potent or reasonable CYP3A inducers is expected to minimize atrasentan systemic exposure, which may minimize efficacy. .
Keep track of Intently (1)pentobarbital will lessen the level or outcome of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Loss of, or diminished response to tofacitinib might arise when coadministered with powerful CYP3A4 inducers
Untimely infants are particularly liable to the depressant effects of barbiturates; if barbiturates are used for the duration of labor and shipping, resuscitation gear really should be obtainable
CYP3A4 inducers may raise the development from the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Carefully observe clients getting ifosfamide with CYP3A4 inducers for toxicities and think about dose adjustment.
pentobarbital will decrease the level or effect of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will increase toxicity of methoxyflurane by raising metabolism. Contraindicated. Increased metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will lessen the level or result of cilostazol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
sodium oxybate and pentobarbital the two increase sedation. Avoid or Use Alternate Drug. Restrict use to people for whom different here treatment method alternatives are inadequate
pentobarbital and olopatadine intranasal each maximize sedation. Avoid or Use Alternate Drug. Coadministration increases threat of CNS despair, which may lead to additive impairment of psychomotor functionality and lead to daytime impairment.
Contraindicated (one)pentobarbital will lessen the level or impact of fostemsavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the extent or outcome of atorvastatin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.